Cotreatment of Hairy Cell Leukemia and Melanoma With theBRAFInhibitor Dabrafenib
نویسندگان
چکیده
منابع مشابه
Hairy cell leukemia-variant.
Hairy cell leukaemia variant is a very rare chronic lymphoproliferative disorder and is closely related to hairy cell leukemia. We hereby describe a case of hairy cell leukaemia variant for the first time in Saudi Arabia. An elderly Saudi man presented with pallor, massive splenomegaly, and moderate hepatomegaly. Hemoglobin was 7.7 g/dl, Platelets were 134 x109/l and white blood count was 140x1...
متن کاملTreatment of hairy-cell leukemia.
AIRY CELL LEUKEMIA (HCL), or leukemic reticuH loendotheliosis, is a chronic lymphoproliferative disease that was first described as a distinct clinicopathologic entity by Bouroncle et a1 in 1958.' It is characterized by mononuclear cells of B-lymphocyte origin in the peripheral blood that have prominent cytoplasmic projections staining with tartrate-resistant acid phosphatase' and by its typica...
متن کاملThe disease with hope: hairy cell leukemia.
Hairy cell leukemia (HCL), comprising 2% of all leukemias, is a chronic disorder characterized by mononuclear cells with prominent cytoplasmic projections. For years, patients with HCL underwent splenectomies and then interferon alpha for treatment, which provided high response rates but low percentages of complete remission. More recent treatments with 2-chlorodeoxyadenosine result in 85%-90% ...
متن کاملGenomics of Hairy Cell Leukemia
Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with unique clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analogs; however, the disease relapses, often repeatedly. The enigmatic pathogenesis of HCL was recently clarified by the discovery of its underlying genetic cause, the BRAF-V600E kinase-activating mutation, which is somatically an...
متن کاملMonoclonal antibodies reactive with hairy cell leukemia.
Monoclonal antibodies reactive with hairy cell leukemia were developed to aid in the diagnosis of this subtype of B cell chronic lymphocytic leukemia and to gain better insight into the origin of hairy cells. Three antibodies were found to be of value in the diagnosis of hairy cell leukemia. Antibody B-ly 2 can be considered a pan-B cell reagent and generally reacts similar to CD22 antibodies. ...
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ژورنال
عنوان ژورنال: Journal of the National Comprehensive Cancer Network
سال: 2015
ISSN: 1540-1405,1540-1413
DOI: 10.6004/jnccn.2015.0004